9/12/2023 0 Comments Talos principle area 2![]() ![]() The current ‘standard-of-care’ dual antiplatelet therapy (DAPT) for patients with ACS undergoing PCI, according to international guidelines, comprises aspirin combined with a potent P2Y purinoceptor 12 (P2Y 12) inhibitor, namely prasugrel or ticagrelor 1, 2, 3, 4, 5, 6. In this Consensus Statement, we summarize the evidence base for these treatment approaches, provide guidance on the assessment of ischaemic and bleeding risks, and provide consensus statements from an international panel of experts to help clinicians to optimize these DAPT approaches for individual patients to improve outcomes.Īntiplatelet therapy is central to the management of acute coronary syndromes (ACS) in patients undergoing percutaneous coronary intervention (PCI). However, these two strategies have not yet been compared in a head-to-head clinical trial. Abbreviation of DAPT duration after 1–6 months, followed by monotherapy with aspirin or a P2Y 12 inhibitor, reduces bleeding without an increase in ischaemic events in patients at high bleeding risk, particularly those without high ischaemic risk. De-escalation of DAPT intensity can reduce bleeding without increasing ischaemic events and can be guided by platelet function testing or genotyping. Either strategy requires assessment of the ischaemic and bleeding risks of each individual. Strategies to reduce bleeding include de-escalation of DAPT intensity (downgrading from potent P2Y 12 inhibitor at conventional doses to either clopidogrel or reduced-dose prasugrel) or abbreviation of DAPT duration. Although this approach reduces ischaemic risk, patients are exposed to a substantial risk of bleeding. Lip ORCID: /0000-0002-7566-1626 29, 30, 31Ĭonventional dual antiplatelet therapy (DAPT) for patients with acute coronary syndromes undergoing percutaneous coronary intervention comprises aspirin with a potent P2Y purinoceptor 12 (P2Y 12) inhibitor (prasugrel or ticagrelor) for 12 months. The Melodies of CreationImmerse yourself in the rich, bittersweet world of The Talos Principle with a stunning soundtrack by master composer Damjan Mravunac (Serious Sam, The Talos Principle), with a guest appearance by Chris Christodoulou (Risk of Rain 1 and 2).De-escalation or abbreviation of dual antiplatelet therapy in acute coronary syndromes and percutaneous coronary intervention: a Consensus Statement from an international expert panel on coronary thrombosis Take a break from puzzle-solving to discover long-buried secrets and strands of forgotten history. Brave New WorldExplore more than a dozen all-new environments, from a city on the brink of a paradigm shift to the varied landscapes of a mysterious island that holds the keys to the future. A Philosophical OdysseyTake the next step forward in the story of The Talos Principle in a thought-provoking, character-driven interactive story with multiple endings penned by returning writers Jonas Kyratzes (The Eternal Cylinder, Clash: Artifacts of Chaos) and Tom Jubert (The Swapper, Subnautica), joined by Verena Kyratzes (The Hand of Merlin, Serious Sam 4). ![]() A variety of new abilities, such as gravity manipulation and mind transference, join the established mechanics of the original Talos Principle, creating a fresh but familiar experience. Finish the game without solving every puzzle, or pursue the rewards of complete mastery. A New Generation of PuzzlesSolve a wide array of puzzles with varying difficulty levels, including clever metapuzzles and highly challenging Gold puzzles. The broken promise of a better tomorrow, the fear of repeating humankind’s mistakes, faith in reason or renouncing humanity altogether - the choices you make and the sides you take will determine the course of events. The more you discover, the more you will be confronted with questions about the nature of the cosmos and the purpose of civilization. ![]() Born into a new world where biological humanity is extinct but human culture lives on in a city of robots, you find yourself swept up in a mind-bending adventure involving a mysterious megastructure hiding enormous powers. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |